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The effect of magnesium on length of stay for pediatric sickle cell pain crisis. Acad Emerg Med 2004 Sep;11(9):968-72 PMID: 15347549

Pubmed ID

15347549

Abstract

OBJECTIVES: To determine the effect of intravenous (IV) magnesium sulfate on the length of stay (LOS) for children admitted with sickle cell pain crisis.

METHODS: This was a single arm study, with historical controls. Hemoglobin SS or Hemoglobin Sbeta degrees children admitted for pain crisis were eligible. Two sequential treatment protocols of IV magnesium sulfate were added to standard inpatient therapy of IV fluids, opioids, and nonsteroidal anti-inflammatory drugs. The initial 12 children received 40 mg/kg (maximum of 1.5 g) of IV magnesium in the emergency department (ED), and eight and 16 hours later. Seven subsequent children received 40 mg/kg (maximum of 2.5 g) of IV magnesium in the ED, and every eight hours for up to four inpatient days. The main outcome measure was LOS, measured in days. Differences in LOS were analyzed between the admission with magnesium, and the two previous admissions meeting the same criteria, using a Wilcoxon signed-rank test for nonparametric paired data.

RESULTS: Nineteen children were enrolled. The results of the two protocols were combined for the analysis. A shorter LOS was found on study admissions (median LOS, 3.0 days compared with 5.0 and 4.0 days for the previous two admissions; p = 0.006).

CONCLUSIONS: IV magnesium appears to decrease the LOS for children with sickle cell pain crisis.

Author List

Brousseau DC, Scott JP, Hillery CA, Panepinto JA

Authors

David Brousseau MD Chief, Professor in the Pediatrics department at Medical College of Wisconsin
Julie A. Panepinto MD, MSPH Professor in the Pediatrics department at Medical College of Wisconsin
John Paul Scott MD Professor in the Pediatrics department at Medical College of Wisconsin




Scopus

2-s2.0-4344570032   20 Citations

MESH terms used to index this publication - Major topics in bold

Adolescent
Anemia, Sickle Cell
Child
Child, Preschool
Drug Administration Schedule
Emergency Service, Hospital
Female
Humans
Infusions, Intravenous
Length of Stay
Magnesium
Male
Pain
jenkins-FCD Prod-336 69ef4a6b262d135130251597d5d39873903802b5