Faculty Collaboration Database

Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection. Immunity 2011 Oct 28;35(4):633-46

Date

10/25/2011

Pubmed ID

22018471

Pubmed Central ID

PMC3444169

DOI

10.1016/j.immuni.2011.08.016

Scopus ID

2-s2.0-80755163540 (requires institutional sign-in at Scopus site)   225 Citations

Abstract

CD4(+) T cells differentiate into multiple effector types, but it is unclear how they form memory T cells during infection in vivo. Profiling virus-specific CD4(+) T cells revealed that effector cells with T helper 1 (Th1) or T follicular helper (Tfh) cell characteristics differentiated into memory cells, although expression of Tfh cell markers declined over time. In contrast to virus-specific effector CD8(+) T cells, increased IL-7R expression was not a reliable marker of CD4(+) memory precursor cells. However, decreased Ly6C and T-bet (Tbx21) expression distinguished a subset of Th1 cells that displayed greater longevity and proliferative responses to secondary infection. Moreover, the gene expression profile of Ly6C(lo)T-bet(int) Th1 effector cells was virtually identical to mature memory CD4(+) T cells, indicating early maturation of memory CD4(+) T cell features in this subset during acute viral infection. This study provides a framework for memory CD4(+) T cell development after acute viral infection.

Author List

Marshall HD, Chandele A, Jung YW, Meng H, Poholek AC, Parish IA, Rutishauser R, Cui W, Kleinstein SH, Craft J, Kaech SM

MESH terms used to index this publication - Major topics in bold

Animals
Antigens, Ly
Cell Proliferation
Gene Expression Regulation
Immunologic Memory
Lymphocytic choriomeningitis virus
Mice
Mice, Inbred C57BL
T-Box Domain Proteins
Th1 Cells