Medical College of Wisconsin
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Generation of effector CD8+ T cells and their conversion to memory T cells. Immunol Rev 2010 Jul;236:151-66

Date

07/20/2010

Pubmed ID

20636815

Pubmed Central ID

PMC4380273

DOI

10.1111/j.1600-065X.2010.00926.x

Scopus ID

2-s2.0-77953749960   129 Citations

Abstract

Immunological memory is a cardinal feature of adaptive immunity. We are now beginning to elucidate the mechanisms that govern the formation of memory T cells and their ability to acquire longevity, survive the effector-to-memory transition, and mature into multipotent, functional memory T cells that self-renew. Here, we discuss the recent findings in this area and highlight extrinsic and intrinsic factors that regulate the cellular fate of activated CD8+ T cells.

Author List

Cui W, Kaech SM

Author

Weiguo Cui PhD Associate Professor in the Microbiology and Immunology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
CD8-Positive T-Lymphocytes
Cell Differentiation
Cell Proliferation
Humans
Immunologic Memory
Interleukin-2
Lymphocyte Activation
Models, Immunological
T-Lymphocytes
jenkins-FCD Prod-398 336d56a365602aa89dcc112f077233607d6a5abc