Faculty Collaboration Database

Lobular carcinoma of the breast metastatic to the epidural space: a potential mimic of giant cell bone tumor. Breast J 2003 Jan-Feb;9(1):44-6

Date

02/01/2003

Pubmed ID

12558671

DOI

10.1046/j.1524-4741.2003.09115.x

Scopus ID

2-s2.0-0037270103

Abstract

We report the case of a 64-year-old woman with a spinal epidural mass. Tissue from a decompression laminectomy disclosed a tumor with numerous osteoclast-like giant cells separated by small, moderately atypical tumor cells. The osteoclast-like giant cells were immunoreactive for vimentin, but negative for epithelial membrane antigen and broad-pectrum cytokeratin. Subsequent breast biopsy revealed a lobular carcinoma of classic type without osteoclast-like giant cells. This is the first reported case in which metastatic breast carcinoma was accompanied by these giant cells but the giant cells were not present at the primary tumor site.

Author List

Iczkowski KA, Pantazis CG, Wollett FC

Author

Kenneth A. Iczkowski MD Professor in the Pathology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Breast Neoplasms
Carcinoma, Lobular
Diagnosis, Differential
Epidural Space
Female
Giant Cell Tumor of Bone
Humans
Middle Aged
Osteoclasts
Spinal Neoplasms