Chlamydia and the adolescent girl. The enzyme immunoassay as a screening tool. Am J Dis Child 1989 Jan;143(1):51-4
Date
01/01/1989Pubmed ID
2642646DOI
10.1001/archpedi.1989.02150130061015Scopus ID
2-s2.0-0024558823 (requires institutional sign-in at Scopus site) 12 CitationsAbstract
To evaluate the enzyme immunoassay for Chlamydia detection in a population of sexually active urban adolescent girls, 100 endocervical screens using both immunoassay and tissue cell culture were performed. Prevalence of Chlamydia trachomatis was 35%, with more than two thirds of infected adolescents being asymptomatic. When compared with cell culture, the immunoassay was determined to have a sensitivity of 74%, a specificity of 98%, and positive and negative predictive values of 96% and 88%, respectively. Adolescents with false-negative immunoassay test results were more likely to lack evidence of cervical inflammation on examination and have lower-titer infections than their peers with positive results. When the immunoassay was matched against culture for test of cure after therapy, a 10% false-positive rate was found. We conclude that the immunoassay is a useful screening technique for detection of Chlamydia in high-risk adolescent populations; however, its limitations with respect to decreased sensitivity in asymptomatic girls and poor positive predictive value in the context of tests of cure must be appreciated.
Author List
Soren K, Willis EMESH terms used to index this publication - Major topics in bold
AdolescentChicago
Chlamydia Infections
Chlamydia trachomatis
Cross-Sectional Studies
False Negative Reactions
Female
Humans
Immunoenzyme Techniques
Mass Screening