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Dexamethasone normalizes brain tumor hemodynamics as indicated by dynamic susceptibility contrast MRI perfusion parameters. Technol Cancer Res Treat 2005 Jun;4(3):245-9 PMID: 15896079

Pubmed ID

15896079

Abstract

The purpose of this study is to demonstrate the utility of dynamic susceptibility contrast (DSC) MRI-derived perfusion parameters to characterize the hemodynamic effects of dexamethasone in a 9L gliosarcoma tumor model. Twenty-four rats underwent intracerebral inoculation with 9L tumor cells. Fifteen were treated with a total of 3mg/kg of dexamethasone on days 10-14 post-inoculation, while the remaining 9 rats served as controls. Fourteen days post-inoculation, MRI images, sensitive to total and micro-vascular cerebral blood flow (CBF), mean transit time (MTT), and intravoxel transit time distributions (TTD)s were obtained using a simultaneous gradient-echo(GE)/spin-echo(SE) DSC-MRI method. Dexamethasone-treated animals had a microvascular (SE) tumor CBF that was 45.9% higher (p = 0.0008) and a MTT that was 47.8% lower (p = 0.0005) than untreated animals. With treatment, there was a non-significant 91.3% increase in total (GE) vascular CBF (p = 0.35), and a significant decrease in MTT (49.1%, p = 0.02). The total vascular and microvascular TTDs from the treated tumors were similar to normal brain, unlike the TTDs in the untreated tumors. These findings demonstrate that DSC-MRI perfusion methods can be used to non-invasively detect the morphological and functional changes in tumor vasculature that occur in response to dexamethasone treatment.

Author List

Quarles CC, Krouwer HG, Rand SD, Schmainda KM

Authors

Scott D. Rand MD, PhD Professor in the Radiology department at Medical College of Wisconsin
Kathleen M. Schmainda PhD Professor in the Radiology department at Medical College of Wisconsin




Scopus

2-s2.0-20444367299   13 Citations

MESH terms used to index this publication - Major topics in bold

Animals
Anti-Inflammatory Agents
Brain Neoplasms
Cerebrovascular Circulation
Contrast Media
Dexamethasone
Gliosarcoma
Magnetic Resonance Imaging
Male
Perfusion
Rats
Rats, Wistar
Regional Blood Flow
jenkins-FCD Prod-256 97250b83e4554f37bec91ca291f44ff4aedcc508