Cardiac injury after 10 gy total body irradiation: indirect role of effects on abdominal organs. Radiat Res 2013 Sep;180(3):247-58
Date
08/08/2013Pubmed ID
23919311Pubmed Central ID
PMC4042860DOI
10.1667/RR3292.1Scopus ID
2-s2.0-84884273934 (requires institutional sign-in at Scopus site) 40 CitationsAbstract
The objective of this study was to determine whether radiation-induced injury to the heart after 10 Gy total body irradiation (TBI) is direct or indirect. Young male WAG/RijCmcr rats received a 10 Gy single dose using TBI, upper hemi-body (UHB) irradiation, lower hemi-body (LHB) irradiation, TBI with the kidneys shielded or LHB irradiation with the intestines shielded. Age-matched, sham-irradiated rats served as controls. The lipid profile, kidney injury, heart and liver morphology and cardiac function were determined up to 120 days after irradiation. LHB, but not UHB irradiation, increased the risk factors for cardiac disease as well as the occurrence of cardiac and kidney injury in a way that was quantitatively and qualitatively similar to that observed after TBI. Shielding of the kidneys prevented the increases in risk factors for cardiac disease. Shielding of the intestines did not prevent the increases in risk factors for cardiac disease. There was no histological evidence of liver injury 120 days after irradiation. Injury to the heart from irradiation appears to be indirect, supporting the notion that injury to abdominal organs, principally the kidneys, is responsible for the increased risk factors for and the occurrence of cardiac disease after TBI and LHB irradiation.
Author List
Lenarczyk M, Lam V, Jensen E, Fish BL, Su J, Koprowski S, Komorowski RA, Harmann L, Migrino RQ, Li XA, Hopewell JW, Moulder JE, Baker JEAuthors
John E. Baker PhD Professor in the Surgery department at Medical College of WisconsinEric S. Jensen DVM Associate Professor in the Research Office department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsBase Sequence
DNA Primers
Heart
Intestines
Kidney
Male
Radiation Dosage
Radiation Injuries, Experimental
Rats
Risk Factors
Whole-Body Irradiation
