Elevated 12- and 20-hydroxyeicosatetraenoic acid in urine of patients with prostatic diseases. Cancer Lett 2006 Feb 28;233(2):219-25
Date
05/11/2005Pubmed ID
15882928DOI
10.1016/j.canlet.2005.03.025Scopus ID
2-s2.0-33644648950 (requires institutional sign-in at Scopus site) 43 CitationsAbstract
The role of eicosanoids (metabolites of arachidonic acid) in prostate diseases is receiving increased attention. We investigated the relationship between the concentrations of urinary free acids of 12- and 20-hydroxyeicosatetraenoic acids (12- and 20-HETE) and the benign prostatic hypertrophy (BPH) and prostate cancer (Pca). Urinary concentrations of 12-HETE and 20-HETE of BPH and Pca patients were significantly higher than normal subjects. After removal of the prostate gland, the urinary concentrations of these eicosanoids decreased to concentrations similar to the normal subjects. These results suggest that urinary free acids of 12-HETE and 20-HETE indicate an abnormality of the prostate gland.
Author List
Nithipatikom K, Isbell MA, See WA, Campbell WBAuthor
William B. Campbell PhD Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
12-Hydroxy-5,8,10,14-eicosatetraenoic AcidAdult
Aged
Chromatography, Liquid
Humans
Hydroxyeicosatetraenoic Acids
Male
Middle Aged
Prostate
Prostatic Hyperplasia
Prostatic Neoplasms
Spectrometry, Mass, Electrospray Ionization