Medical College of Wisconsin
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Diffusion-weighted MRI as a biomarker for treatment response in glioma. CNS Oncol 2012 Nov;1(2):169-80 PMID: 23936625 PMCID: PMC3734866

Pubmed ID



Diffusion-weighted imaging (DWI) is a powerful MRI method, which probes abnormalities of tissue structure by detecting microscopic changes in water mobility at a cellular level beyond what is available with other imaging techniques. Accordingly, DWI has the potential to identify pathology before gross anatomic changes are evident on standard anatomical brain images. These features of tissue characterization and earlier detection are what make DWI particularly appealing for the evaluation of gliomas and the newer therapies where standard anatomical imaging is proving insufficient. This article focuses on the basic principles and applications of DWI, and its derived parameter, the apparent diffusion coefficient, for the purposes of diagnosis and evaluation of glioma, especially in the context of monitoring response to therapy.

Author List

Schmainda KM


Kathleen M. Schmainda PhD Professor in the Biophysics department at Medical College of Wisconsin


2-s2.0-84906738491   22 Citations

MESH terms used to index this publication - Major topics in bold

Brain Neoplasms
Diffusion Magnetic Resonance Imaging
jenkins-FCD Prod-321 98992d628744e349846c2f62ac68f241d7e1ea70