Toll-like receptor genetic variants are associated with Gram-negative infections in VLBW infants. J Perinatol 2013 Oct;33(10):772-7
Date
07/23/2013Pubmed ID
23867959Pubmed Central ID
PMC4465440DOI
10.1038/jp.2013.80Scopus ID
2-s2.0-84885018938 (requires institutional sign-in at Scopus site) 26 CitationsAbstract
OBJECTIVE: To test the hypothesis that single-nucleotide polymorphisms (SNPs) in Toll-like receptor (TLR) genes alter susceptibility to bacterial infections and modulate white blood cell (WBC) counts during infections in very low birth weight (VLBW) infants (birth weight <1500 g).
STUDY DESIGN: VLBW infants recruited in a multicenter study were genotyped for nine functional TLR SNPs and associations between SNPs and infection rates examined. WBC counts obtained during infections were compared among infants with and without SNPs.
RESULT: In our cohort (n=408), 90 infants developed bacterial infections. Presence of TLR4 (rs4986790 and rs4986791) variants were associated with Gram-negative (G-ve) infections. Female infants heterozygous for the X-linked IRAK1 (rs1059703) SNP had less G-ve infections. In regression models controlling for confounders, the TLR4 (rs4986790) SNP was associated with increased G-ve infections. The TLR5 (rs5744105) variant was associated with elevated WBC counts during infections.
CONCLUSION: TLR genetic variants can contribute to increased risk of bacterial infections and altered immune responses in VLBW infants.
Author List
Sampath V, Mulrooney NP, Garland JS, He J, Patel AL, Cohen JD, Simpson PM, Hines RNAuthor
Pippa M. Simpson PhD Adjunct Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
FemaleGenetic Predisposition to Disease
Genetic Variation
Gram-Negative Bacterial Infections
Humans
Immunity, Innate
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases
Infant, Very Low Birth Weight
Interleukin-1 Receptor-Associated Kinases
Leukocyte Count
Logistic Models
Male
Polymorphism, Single Nucleotide
Risk Factors
Toll-Like Receptor 4
Toll-Like Receptor 5
Toll-Like Receptors
