Mechanisms regulating cerebral blood flow as therapeutic targets. Curr Opin Investig Drugs 2004 Sep;5(9):952-6
Date
10/27/2004Pubmed ID
15503650Scopus ID
2-s2.0-13244257651 (requires institutional sign-in at Scopus site) 32 CitationsAbstract
Regulation of cerebral blood flow (CBF) is critical for the maintenance of neural function and hence survival of the organism. Since the brain does not store glycogen, unlike muscle, a constant supply of glucose and oxygen are needed for the minute-by-minute demands of cerebral function. This review focuses on important lipid mediators that act as reciprocal regulators of cerebral artery diameter and their potential as targets for therapeutic intervention in diseases such as ischemia, stroke and subarachnoid hemorrhage. Cytochrome P450 metabolism of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) or epoxyeicosatrienoic acids (EETs) provides a mechanism for the constriction and relaxation of cerebral arteries, respectively. Additionally, EETs have mitogenic potential and may contribute to angiogenesis in the brain, which has important implications during recovery from cerebral injury. Finally, we discuss novel inhibitors of 20-HETE formation and actions as well as interventions to enhance EET production in cerebrovascular disease.
Author List
Pratt PF, Medhora M, Harder DRMESH terms used to index this publication - Major topics in bold
AnimalsBrain
Cerebral Arteries
Cerebrovascular Circulation
Cerebrovascular Disorders
Cytochrome P-450 Enzyme System
Humans
