Faculty Collaboration Database

Effect of extracorporeal membrane oxygenation on leukocyte function in neonates. Artif Organs 1991 Feb;15(1):23-8

Date

02/01/1991

Pubmed ID

1998487

DOI

10.1111/j.1525-1594.1991.tb00755.x

Scopus ID

2-s2.0-0025964946 (requires institutional sign-in at Scopus site)   44 Citations

Abstract

The impact of extracorporeal membrane oxygenation (ECMO) on neonatal leukocyte content and function was examined in six patients. Patients were treated with ECMO for a mean of 134 h (range 44-246 h). Absolute neutrophil counts decreased from 14679 +/- 2291/mm3 to 7791 +/- 1672/mm3 after 2 h of ECMO. However, neutrophil phagocytosis and oxidative burst remained unchanged during the first 48 h of bypass. Monocyte counts also decreased during bypass, and at times were undetectable in 50% of patients. Monocyte HLA-DR content was decreased compared to normal cord blood prior to initiation of ECMO, and remained low throughout ECMO. However, the content increased significantly after termination of bypass. Plasma C3a levels increased transiently, paralleled by an increase in neutrophil CR3 expression. While moribund infants had some impairment of host defenses prior to ECMO, there was no further impact of ECMO per se on the parameters measured, other than transient complement activation and decreased monocyte counts.

Author List

Hocker JR, Wellhausen SR, Ward RA, Simpson PM, Cook LN

Author

Pippa M. Simpson PhD Adjunct Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Complement Activation
Complement C3a
Extracorporeal Membrane Oxygenation
HLA-DR Antigens
Humans
Infant, Newborn
Infant, Newborn, Diseases
Leukocyte Count
Leukocytes
Phagocytosis