Polyetheretherketone as a biomaterial for spinal applications. Biomaterials 2006 Jan;27(3):324-34
Date
08/24/2005Pubmed ID
16115677DOI
10.1016/j.biomaterials.2005.07.011Scopus ID
2-s2.0-26844437429 (requires institutional sign-in at Scopus site) 462 CitationsAbstract
Threaded lumbar interbody spinal fusion devices (TIBFD) made from titanium have been reported to be 90% effective for single-level lumbar interbody fusion, although radiographic determination of fusion has been intensely debated in the literature. Using blinded radiographic, biomechanic, histologic, and statistical measures, we evaluated a radiolucent polyetheretherketone (PEEK)-threaded interbody fusion device packed with autograft or rhBMP-2 on an absorbable collagen sponge in 13 sheep at 6 months. Radiographic fusion, increased spinal level biomechanical stiffness, and histologic fusion were demonstrated for the PEEK cages filled with autograft or rhBMP-2 on a collagen sponge. No device degradation or wear debris was observed. Only mild chronic inflammation consisting of a few macrophages was observed in peri-implant tissues. Based on these results, the polymeric biomaterial PEEK may be a useful biomaterial for interbody fusion cages due to the polymer's increased radiolucency and decreased stiffness.
Author List
Toth JM, Wang M, Estes BT, Scifert JL, Seim HB 3rd, Turner ASAuthors
Jeffrey M. Toth PhD Associate Dean for Research in the School of Dentistry department at Marquette UniversityMei Wang PhD Associate Professor in the Orthopaedic Surgery department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsBenzophenones
Biocompatible Materials
Biomechanical Phenomena
Bone Morphogenetic Protein 2
Bone Morphogenetic Proteins
Bone Transplantation
Diskectomy
Growth Substances
Guided Tissue Regeneration
Implants, Experimental
Inflammation
Ketones
Lumbar Vertebrae
Models, Animal
Osseointegration
Osteogenesis
Polyethylene Glycols
Polymers
Recombinant Proteins
Sheep
Spinal Fusion
Spinal Injuries
Transforming Growth Factor beta