Faculty Collaboration Database

Cribriform adenocarcinoma of the lung: clinicopathologic, immunohistochemical, and molecular analysis of 15 cases of a distinctive morphologic subtype of lung adenocarcinoma. Mod Pathol 2014 Aug;27(8):1063-72

Date

01/07/2014

Pubmed ID

24390215

DOI

10.1038/modpathol.2013.227

Scopus ID

2-s2.0-84905442619 (requires institutional sign-in at Scopus site)   28 Citations

Abstract

Lung adenocarcinoma is characterized by marked heterogeneity and may be composed of an admixture of histologic growth patterns, including acinar, papillary, solid, and lepidic (bronchioloalveolar). Tumors displaying a prominent or predominant cribriform architecture are rare and most often confused for metastases from other organs. We report the clinical, histologic, immunohistochemical, and molecular features in 15 primary lung adenocarcinomas with a predominant cribriform histology. All patients were adults between 30 and 80 years of age (median: 64), and all but one reported a history of heavy cigarette smoking. All cases showed a predominant (>70%) cribriform architecture that resembled a variety of tumors arising in other organs, including breast, prostate, ovary, pancreas, uterus, colon, and thyroid. Immunohistochemical stains showed a phenotype consistent with a primary lung tumor (ie, TTF1+/CK7+), with negative results for other markers. Molecular analysis in six cases showed that none harbored an EGFR-activating mutation. KRAS mutation was detected in one case, and an ALK1 and ROS1 gene rearrangement were each detected in an additional two cases. Cribriform adenocarcinomas of the lung represent a distinctive histologic subtype of lung cancer that may be morphologically difficult to differentiate from metastases with a predominant cribriform architecture.

Author List

Mackinnon AC Jr, Luevano A, de Araujo LC, Rao N, Le M, Suster S

MESH terms used to index this publication - Major topics in bold

Activin Receptors, Type II
Adenocarcinoma
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
DNA Mutational Analysis
Diagnosis, Differential
ErbB Receptors
Female
Gene Rearrangement
Genetic Predisposition to Disease
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Lung Neoplasms
Male
Middle Aged
Mutation
Phenotype
Predictive Value of Tests
Protein-Tyrosine Kinases
Proto-Oncogene Proteins
Proto-Oncogene Proteins p21(ras)
Retrospective Studies
ras Proteins