Faculty Collaboration Database

Activated partial thromboplastin time and minor coagulopathies. Am J Clin Pathol 1979 Jan;71(1):22-5

Date

01/01/1979

Pubmed ID

420168

DOI

10.1093/ajcp/71.1.22

Scopus ID

2-s2.0-0018394956 (requires institutional sign-in at Scopus site)   28 Citations

Abstract

Five commercially available activated partial thromboplastin time (APTT) test systems were compared with the kaolin partial thromboplastin time (KPTT) method to determine sensitivity in detecting minor coagulation defects. All reagent systems detected severe factor VIII-, IX-, and XI-deficient hemophilia. Homozygous states of factor XII deficiency, Fletcher factor deficiency, and high-molecular-weight kininogen deficiency (Fitzgerald trait) also showed abnormally long APTTs by all systems. Of 19 samples from patients with deficiencies of factors XII, VIII, IX, XI, and II ranging from 2.5 to 52%, eight had deficiencies that were not detected by reagent A (ellagic acid); two, by reagent B (ellagic acid); two, by reagent C (kaolin); one, by reagent D (silica); one, by the KPTT method. All deficiencies were detected by reagent E (celite). Heparin effect on plasma was less well detected by reagent A (ellagic acid) than with the other test systems. APTT test systems can vary greatly in their abilities to detect minor coagulation abnormalities.

Author List

Hathaway WE, Assmus SL, Montgomery RR, Dubansky AS

Author

Robert R. Montgomery MD Adjunct Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Blood Coagulation Disorders
Blood Coagulation Tests
Female
Humans
Male
Methods
Reference Values
Thromboplastin