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Severe aplastic anaemia: a prospective study of the effect of androgens or transplantation on haematological recovery and survival. Clin Haematol 1978 Oct;7(3):587-95 PMID: 363330

Pubmed ID

363330

Abstract

A prospective study was performed (1) to evaluate the role of androgens in treatment of severe aplastic anaemia, and (2) to compare the efficacy of early bone marrow transplantation with more conventional therapy for severe marrow aplasia. Results fail to support a beneficial effect of androgens on the course of patients with severe aplastic anaemia. In contrast, histocompatible bone marrow transplantation significantly improves survival and haematological recovery. Alternative therapies should be carefully evaluated for non-transplantable patients with severe marrow aplasia.

Author List

Camitta BM, Thomas ED

Author

Bruce M. Camitta MD Clinical Professor in the Medicine department at Medical College of Wisconsin




Scopus

2-s2.0-0018021827   29 Citations

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Aged
Androgens
Anemia, Aplastic
Bone Marrow Transplantation
Child
Child, Preschool
Female
Humans
Male
Middle Aged
Prospective Studies
Transplantation, Homologous
jenkins-FCD Prod-353 9ccd8489072cb19f5b9f808bb23ed672c582f41e