Incidence and survival of desmoplastic melanoma in the United States, 1992-2007. J Cutan Pathol 2011 Aug;38(8):616-24
Date
04/27/2011Pubmed ID
21518379DOI
10.1111/j.1600-0560.2011.01704.xScopus ID
2-s2.0-79960554588 (requires institutional sign-in at Scopus site) 70 CitationsAbstract
BACKGROUND: Desmoplastic melanoma (DM) represents a relatively rare malignancy. The aim of this study was to describe the incidence and survival of DM in the United States.
METHODS: Incidence and survival data were obtained from the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) program, 1992-2007. Kaplan-Meier and Cox proportional hazards regression methods were used to calculate the survival rates and hazard ratios for DM-specific death.
RESULTS: We identified 1129 DM patients from SEER 13 registries, with 64% in men, 37% in women and most (96.8%) occurring in White populations. The incidence rates per 1,000,000 were 1.3 (female), 3.0 (male) and 2.0 (both). The annual percentage change for incidence was 4.6 (95% confidence interval: 2.9-6.5) from 1992 to 2007. The 5-year and 10-year DM-specific survival rates from SEER 17 registries were 84.8 and 79.2%. The 5-year DM-specific survival rates by stage ranged from 90.9% (local) to 51.5% (distant). Independent predictors of mortality from DM included age, anatomic site, thickness, ulceration, lymph node and surgery.
CONCLUSIONS: The incidence of DM has been increasing steadily over the past 15 years. Older age, anatomic site of the head and neck, tumor thickness >2 mm, ulceration, lymph node involvement and non-receipt of surgery are associated with lower survival.
Author List
Feng Z, Wu X, Chen V, Velie E, Zhang ZAuthor
Ellen Velie PhD, MPH Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Aged, 80 and over
Child
Female
Head and Neck Neoplasms
Humans
Incidence
Kaplan-Meier Estimate
Lymph Nodes
Male
Melanoma
Middle Aged
Proportional Hazards Models
Registries
Skin Neoplasms
Survival Rate
United States
Young Adult