Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model. Eur J Pharmacol 2006 Feb 15;531(1-3):126-32
Date
02/04/2006Pubmed ID
16455070DOI
10.1016/j.ejphar.2005.12.031Scopus ID
2-s2.0-32044448692 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
Closed head injury induces cerebral oxidative stress. The efficacy of a Mn (III) porphyrin catalytic antioxidant was assessed in a mouse closed head injury model. Mice were subjected to closed head injury and treated 15 min later with an i.v. bolus of vehicle or 3 mg/kg MnTE-2-PyP5+. Aconitase activity, Fluoro-Jade staining, glial fibrillary acidic protein immunoreactivity, and rotarod falling latencies were measured. Closed head injury altered all variables. MnTE-2-PyP5+ had no effect on any variable with the exception of attenuation of aconitase inactivation at 2 h post-closed head injury. In a second experiment, mice received 3 mg/kg or 6 mg/kg MnTE-2-PyP5+ or vehicle i.v. 15 min post-closed head injury. Rotarod and Morris water maze latencies were measured. Closed head injury altered performance in both tests. No statistically significant effect of MnTE-2-PyP5+ was observed. We conclude that single dose MnTE-2-PyP5+ does not alter outcome in this mouse closed head injury model.
Author List
Leinenweber SB, Sheng H, Lynch JR, Wang H, Batinić-Haberle I, Laskowitz DT, Crapo JD, Pearlstein RD, Warner DSMESH terms used to index this publication - Major topics in bold
Aconitate HydrataseAnimals
Antioxidants
Body Weight
Cerebral Cortex
Dose-Response Relationship, Drug
Glial Fibrillary Acidic Protein
Head Injuries, Closed
Immunohistochemistry
Injections, Intravenous
Male
Manganese
Maze Learning
Metalloporphyrins
Mice
Mice, Inbred C57BL
Motor Activity
Rotarod Performance Test
Time Factors