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Core fucosylation and IgG function in NAIT. Blood 2014 Jan 23;123(4):463-4 PMID: 24458274 PMCID: PMC3901063

Pubmed ID

24458274

DOI

10.1182/blood-2013-12-539965

Abstract

In this issue of Blood, Kapur et al show that maternal human platelet-specific antigen 1a (HPA 1a)-specific antibodies causing neonatal alloimmune thrombocytopenia (NAIT) possess oligosaccharides that are deficient in "core fucose" residues and appear to be more effective than fucosylated antibodies in promoting phagocytosis of antibody-coated platelets.

Author List

Aster RH

Author

Richard H. Aster MD Professor in the Medicine department at Medical College of Wisconsin




Scopus

2-s2.0-84893090587   2 Citations

MESH terms used to index this publication - Major topics in bold

Blood Platelets
Female
Humans
Immunoglobulin Fc Fragments
Immunoglobulin G
Isoantibodies
Pregnancy
Thrombocytopenia, Neonatal Alloimmune
jenkins-FCD Prod-353 9ccd8489072cb19f5b9f808bb23ed672c582f41e