Core fucosylation and IgG function in NAIT. Blood 2014 Jan 23;123(4):463-4
Date
01/25/2014Pubmed ID
24458274Pubmed Central ID
PMC3901063DOI
10.1182/blood-2013-12-539965Scopus ID
2-s2.0-84893090587 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
In this issue of Blood, Kapur et al show that maternal human platelet-specific antigen 1a (HPA 1a)-specific antibodies causing neonatal alloimmune thrombocytopenia (NAIT) possess oligosaccharides that are deficient in "core fucose" residues and appear to be more effective than fucosylated antibodies in promoting phagocytosis of antibody-coated platelets.
Author List
Aster RHMESH terms used to index this publication - Major topics in bold
Blood PlateletsFemale
Humans
Immunoglobulin Fc Fragments
Immunoglobulin G
Isoantibodies
Pregnancy
Thrombocytopenia, Neonatal Alloimmune