von Willebrand's disease antigen II. A new plasma and platelet antigen deficient in severe von Willebrand's disease. J Clin Invest 1978 Jun;61(6):1498-507
Date
06/01/1978Pubmed ID
307007Pubmed Central ID
PMC372676DOI
10.1172/JCI109070Scopus ID
2-s2.0-0017889090 (requires institutional sign-in at Scopus site) 85 CitationsAbstract
Factor VIII-related antigen (VIIIag) is deficient in plasma and platelets of patients with severe von Willebrand's disease. This study reports a second von Willebrand's disease antigen (vWagII), distinct from VIIIag, that is also deficient in the platelets and plasma of patients with severe von Willebrand's disease. VIIIag and vWagII are separable by molecular exclusion chromatography, sucrose density gradient ultracentrifugation, and crossed immunoelectrophoresis. They show reactions of immunologic nonidentity with each other, and thus, do not share a precursor-product relationship. vWagII is released from normal platelets during blood clotting, accounting for a fourfold higher concentration of vWagII in serum over plasma.
Author List
Montgomery RR, Zimmerman TSAuthor
Robert R. Montgomery MD Adjunct Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AntigensBlood Coagulation
Blood Platelets
Centrifugation, Density Gradient
Chromatography, Gel
Humans
Immunoelectrophoresis, Two-Dimensional
Molecular Weight
Plasma
von Willebrand Diseases
von Willebrand Factor
