Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Medullary serotonin neurons and their roles in central respiratory chemoreception. Respir Physiol Neurobiol 2010 Oct 31;173(3):256-63 PMID: 20226279 PMCID: PMC4554718


Much progress has been made in our understanding of central chemoreception since the seminal experiments of Fencl, Loeschcke, Mitchell and others, including identification of new brainstem regions and specific neuron types that may serve as central "sensors" of CO(2)/pH. In this review, we discuss key attributes, or minimal requirements a neuron/cell must possess to be defined as a central respiratory chemoreceptor, and summarize how well each of the various candidates fulfill these minimal criteria-especially the presence of intrinsic chemosensitivity. We then discuss some of the in vitro and in vivo evidence in support of the conclusion that medullary serotonin (5-HT) neurons are central chemoreceptors. We also provide an additional hypothesis that chemosensitive medullary 5-HT neurons are poised to integrate multiple synaptic inputs from various other sources thought to influence ventilation. Finally, we discuss open questions and future studies that may aid in continuing our advances in understanding central chemoreception.

Author List

Hodges MR, Richerson GB


Matthew R. Hodges PhD Associate Professor in the Physiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Medulla Oblongata

View this publication's entry at the Pubmed website PMID: 20226279
jenkins-FCD Prod-141 f776ee82366dc5656a368d51cce32734d2f9b9a0