Correcting the effects of background microcirculation in the measurement of arterial input functions using dynamic susceptibility contrast MRI of the brain. Magn Reson Imaging 2006 Jun;24(5):619-23
Date
06/01/2006Pubmed ID
16735184DOI
10.1016/j.mri.2005.09.014Scopus ID
2-s2.0-33646850867 (requires institutional sign-in at Scopus site) 9 CitationsAbstract
In dynamic susceptibility contrast MRI, the shape of the arterial input function (AIF) is commonly obtained in the near vicinity of the middle cerebral artery (MCA). However, the tissue regions where the AIF is sampled also have significant perfusion, which contributes to T(2)* changes. We investigate whether correction of this effect will introduce significant changes in the measurement of the AIF and, subsequently, the assessment of the mean transit time (MTT). Clinical dynamic susceptibility data from 13 patients with brain tumors were analyzed. Patients received either single or double doses of Magnevist followed by a saline flush through a power injector. In the correction procedure, DeltaR(2)* was sampled in a region of gray matter approximately 1-2 cm away from the MCA and then subtracted from the DeltaR(2)* sampled in the immediate vicinity of the MCA. We demonstrate that in the brain, this correction of DeltaR(2)* due to tissue perfusion leads to a narrower width of the AIF curve obtained with DeltaR(2)* (mean+/-S.D.=7.3+/-2.0 and 6.4+/-1.7 s, before and after correction, respectively, P<.001 using a two-tailed paired t-test). Furthermore, the peak of the AIF also moved to a slightly earlier time relative to the time of arrival (mean+/-S.D.=4.7+/-0.9 and 4.3+/-0.8 s, before and after correction, with P<.001). With the use of the corrected AIF, the measured MTT had increased values in areas of both gray and white matter.
Author List
Thornton RJ, Jones JY, Wang ZJAuthor
Test W. User test user title in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AlgorithmsArtifacts
Brain
Cerebral Arteries
Cerebrovascular Circulation
Contrast Media
Humans
Image Enhancement
Image Interpretation, Computer-Assisted
Information Storage and Retrieval
Magnetic Resonance Imaging
Magnetics
Microcirculation
Phantoms, Imaging
Reproducibility of Results
Sensitivity and Specificity