Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Radiation dose responses for chemoradiation therapy of pancreatic cancer: an analysis of compiled clinical data using biophysical models. Pract Radiat Oncol 2014 Jan-Feb;4(1):13-9 PMID: 24621418

Pubmed ID

24621418

DOI

10.1016/j.prro.2013.01.005

Abstract

PURPOSE: We analyzed recent clinical data obtained from chemoradiation of unresectable, locally advanced pancreatic cancer (LAPC) in order to examine possible benefits from radiation therapy dose escalation.

METHODS AND MATERIALS: A modified linear quadratic model was used to fit clinical tumor response and survival data of chemoradiation treatments for LAPC reported from 20 institutions. Biophysical radiosensitivity parameters were extracted from the fits.

RESULTS: Examination of the clinical data demonstrated an enhancement in tumor response with higher irradiation dose, an important clinical result for palliation and quality of life. Little indication of improvement in 1-year survival with increased radiation dose was observed. Possible dose escalation schemes are proposed based on calculations of the biologically effective dose required for a 50% tumor response rate.

CONCLUSIONS: Based on the evaluation of tumor response data, the escalation of radiation dose presents potential clinical benefits which when combined with normal tissue complication analyses may result in improved treatment outcome for locally advanced pancreatic cancer patients.

Author List

Moraru IC, Tai A, Erickson B, Li XA

Authors

Beth A. Erickson MD Professor in the Radiation Oncology department at Medical College of Wisconsin
X Allen Li PhD Professor in the Radiation Oncology department at Medical College of Wisconsin
An Tai PhD Assistant Professor in the Radiation Oncology department at Medical College of Wisconsin




Scopus

2-s2.0-84890883076   13 Citations

MESH terms used to index this publication - Major topics in bold

Biophysical Phenomena
Chemoradiotherapy
Dose-Response Relationship, Radiation
Humans
Linear Models
Models, Biological
Pancreatic Neoplasms
Radiotherapy Dosage
Treatment Outcome
jenkins-FCD Prod-353 9ccd8489072cb19f5b9f808bb23ed672c582f41e