Exercise and vascular function: how much is too much? Can J Physiol Pharmacol 2014 Jul;92(7):551-7
Date
05/31/2014Pubmed ID
24873760Pubmed Central ID
PMC4398063DOI
10.1139/cjpp-2013-0486Scopus ID
2-s2.0-84903277861 (requires institutional sign-in at Scopus site) 44 CitationsAbstract
Exercise is a powerful therapy for preventing the onset of and slowing the progression of cardiovascular disease. Increased shear stress during exercise improves vascular homeostasis by both decreasing reactive oxygen species and increasing nitric oxide bioavailability in the endothelium. While these observations are well accepted as they apply to individuals at risk for cardiovascular disease, less is known about how exercise, especially intense exercise, affects vascular function in healthy individuals. This review highlights examples of how vascular function can paradoxically be impaired in otherwise healthy individuals by extreme levels of exercise, with a focus on the causative role that reactive oxygen species play in this impairment.
Author List
Durand MJ, Gutterman DDAuthor
Matt Durand PhD Associate Professor in the Physical Medicine and Rehabilitation department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Blood VesselsCardiovascular Diseases
Exercise
Humans
Nitric Oxide
Reactive Oxygen Species