Faculty Collaboration Database

Management of the pregnant woman with Marfan syndrome complicated by ascending aorta dilation. Arch Gynecol Obstet 2014 Oct;290(4):797-802

Date

06/27/2014

Pubmed ID

24966118

DOI

10.1007/s00404-014-3307-4

Scopus ID

2-s2.0-84921968642 (requires institutional sign-in at Scopus site)   19 Citations

Abstract

INTRODUCTION: Marfan syndrome is a disorder of connective tissue associated with progressive dilation of the aorta and potential risk for aortic dissection. Women with Marfan syndrome who are, or wish to become, pregnant represent a unique and challenging patient population due to a risk for accelerated aortic growth and aortic dissection during pregnancy. Risk for aortic complications during pregnancy is related to the dimensions of the ascending aorta. Women with an aortic diameter ≥4.5 cm at the start of pregnancy are at higher risk for aortic dissection, and an aortic dimension >4.0 cm is considered a relative contraindication to pregnancy in the setting of Marfan syndrome.

CONCLUSION: Multidisciplinary care involving specialists familiar with Marfan syndrome should be emphasized before, during, and after pregnancy with the involvement of Maternal Fetal Medicine, Genetics, Cardiology, Cardiothoracic Surgery, Anesthesia, and other specialties on a case-by-case basis. We review the important aspects of the evaluation and management of pregnant women with Marfan syndrome.

Author List

Cox DA, Ginde S, Kuhlmann RS, Earing MG

Author

Salil Ginde MD, MPH Associate Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adrenergic beta-Antagonists
Anesthesia, Epidural
Anesthesia, Obstetrical
Aorta
Aortic Aneurysm
Cardiovascular Surgical Procedures
Counseling
Delivery, Obstetric
Diagnostic Imaging
Dilatation, Pathologic
Female
Humans
Marfan Syndrome
Obstetric Labor Complications
Patient Care Team
Postnatal Care
Preconception Care
Pregnancy
Pregnancy Complications, Cardiovascular
Risk