Faculty Collaboration Database

Lesions in the cerebellar fastigial nucleus have a small effect on the hyperpnea needed to meet the gas exchange requirements of submaximal exercise. J Appl Physiol (1985) 2006 Oct;101(4):1199-206

Date

06/10/2006

Pubmed ID

16763105

DOI

10.1152/japplphysiol.00330.2006

Scopus ID

2-s2.0-33749371106 (requires institutional sign-in at Scopus site)   8 Citations

Abstract

The purpose of this study was to test the hypothesis that an intact cerebellar fastigial nucleus (CFN) is necessary for the hyperpnea to meet the gas exchange needs of submaximal exercise. Bilateral stainless steel microtubules were implanted in the cerebellum inside (n = 12) or outside (n = 2) the CFN for injection (0.5 to 10 microl) of the neurotoxin ibotenic acid. All goats had difficulty maintaining normal posture and walking for up to 1 mo after the implantation of the microtubules and again for hours or days after the neurotoxin was injected. Postmortem histology indicated there were 55% fewer living neurons (P < 0.001, n = 9, 3,720 +/- 553 vs. 1,670 +/- 192) in the CFN of the experimental goats compared with a control group of goats. As is typical for goats before implantation of the microtubules, the decrease in arterial Pco(2) from rest during mild and moderate treadmill exercise was 2.0 +/- 0.39 and 3.5 +/- 0.45 Torr, respectively. Implantation of the microtubules did not significantly change this exercise hyperventilation. However, neurotoxic lesioning with 10 mul ibotenic acid significantly (P < 0.05) attenuated the decrease in arterial Pco(2) by 1.3 and 2.8 Torr at the first and second workload, respectively. The modest attenuation of the exercise hypocapnia at both workloads in CFN-lesioned goats suggests that the CFN is part of the control system that enables the ventilatory response to meet the gas exchange requirements of submaximal exercise.

Author List

Martino PF, Davis S, Opansky C, Krause K, Bonis JM, Czerniak SG, Pan LG, Qian B, Forster HV

Author

Hubert V. Forster PhD Professor in the Physiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Cerebellar Nuclei
Exercise Test
Female
Goats
Hyperventilation
Ibotenic Acid
Male
Methysergide
Models, Animal
Neurons
Oxygen Consumption
Physical Conditioning, Animal
Pulmonary Gas Exchange
Respiration
Vasoconstrictor Agents