Mechanisms and molecular probes of sirtuins. Chem Biol 2008 Oct 20;15(10):1002-13
Date
10/23/2008Pubmed ID
18940661Pubmed Central ID
PMC2626554DOI
10.1016/j.chembiol.2008.09.009Scopus ID
2-s2.0-53649086367 (requires institutional sign-in at Scopus site) 128 CitationsAbstract
Sirtuins are critical regulators of many cellular processes, including insulin secretion, the cell cycle, and apoptosis. Sirtuins are associated with a variety of age-associated diseases such as type II diabetes, obesity, and Alzheimer's disease. A thorough understanding of sirtuin chemical mechanisms will aid toward developing novel therapeutics that regulate metabolic disorders and combat associated diseases. In this review, we discuss the unique deacetylase mechanism of sirtuins and how this information might be employed to develop inhibitors and other molecular probes for therapeutic and basic research applications. We also cover physiological regulation of sirtuin activity and how these modes of regulation may be exploited to manipulate sirtuin activity in live cells. Development of molecular probes and drugs that specifically target sirtuins will further understanding of sirtuin biology and potentially afford new treatments of several human diseases.
Author List
Smith BC, Hallows WC, Denu JMAuthor
Brian C. Smith PhD Associate Professor in the Biochemistry department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AcetylationAnimals
Biomarkers
Histone Acetyltransferases
Humans
Molecular Probes
NAD
Sirtuins
