Altered intrinsic hippocmapus declarative memory network and its association with impulsivity in abstinent heroin dependent subjects. Behav Brain Res 2014 Oct 01;272:209-17
Date
07/11/2014Pubmed ID
25008351Pubmed Central ID
PMC4144330DOI
10.1016/j.bbr.2014.06.054Scopus ID
2-s2.0-84904747753 (requires institutional sign-in at Scopus site) 22 CitationsAbstract
Converging evidence suggests that addiction can be considered a disease of aberrant learning and memory with impulsive decision-making. In the past decades, numerous studies have demonstrated that drug addiction is involved in multiple memory systems such as classical conditioned drug memory, instrumental learning memory and the habitual learning memory. However, most of these studies have focused on the contributions of non-declarative memory, and declarative memory has largely been neglected in the research of addiction. Based on a recent finding that hippocampus, as a core functioning region of declarative memory, was proved biased the decision-making process based on past experiences by spreading associated reward values throughout memory. Our present study focused on the hippocampus. By utilizing seed-based network analysis on the resting-state functional MRI datasets with the seed hippocampus we tested how the intrinsic hippocampal memory network altered toward drug addiction, and examined how the functional connectivity strength within the altered hippocampal network correlated with behavioral index 'impulsivity'. Our results demonstrated that HD group showed enhanced coherence between hippocampus which represents declarative memory system and non-declarative reward-guided learning memory system, and also showed attenuated intrinsic functional link between hippocampus and top-down control system, compared to the CN group. This alteration was furthered found to have behavioral significance over the behavioral index 'impulsivity' measured with Barratt Impulsiveness Scale (BIS). These results provide insights into the mechanism of declarative memory underlying the impulsive behavior in drug addiction.
Author List
Zhai TY, Shao YC, Xie CM, Ye EM, Zou F, Fu LP, Li WJ, Chen G, Chen GY, Zhang ZG, Li SJ, Yang ZMESH terms used to index this publication - Major topics in bold
AdultBrain Mapping
Heroin Dependence
Hippocampus
Humans
Impulsive Behavior
Magnetic Resonance Imaging
Male
Memory
Neural Pathways
Psychometrics
Rest
