Vital organ blood flow with the impedance threshold device. Crit Care Med 2006 Dec;34(12 Suppl):S466-73
Date
11/23/2006Pubmed ID
17114979DOI
10.1097/01.CCM.0000246013.47237.86Scopus ID
2-s2.0-33751089794 (requires institutional sign-in at Scopus site) 19 CitationsAbstract
OBJECTIVE: The purpose of this study is to review cardiopulmonary resuscitation hemodynamics and vital organ blood flow in animal models with the use of the impedance threshold device (ITD) and to correlate these findings with the results of human clinical trials.
RESULTS: Animal studies have demonstrated near normalization of cerebral blood flow and an increase between 50% and 100% in cardiac blood flow with use of the ITD. Coincident coronary perfusion pressure is significantly increased with the ITD. Results of human clinical trials generally reflect the data seen in animal models, with near normal blood pressure during active compression-decompression cardiopulmonary resuscitation and the ITD, near doubling of blood pressure with standard cardiopulmonary resuscitation plus the ITD, and significantly increased short-term survival rates.
CONCLUSIONS: Improved vital organ perfusion with ITD use during cardiopulmonary resuscitation is an important advance in resuscitation. Incorporation of the ITD into protocols that improve other aspects of the care of patients during cardiac arrest and after successful resuscitation should result in further benefit from the ITD.
Author List
Aufderheide TP, Lurie KGAuthor
Tom P. Aufderheide MD Professor in the Emergency Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBlood Pressure
Cardiopulmonary Resuscitation
Cerebrovascular Circulation
Clinical Trials as Topic
Coronary Circulation
Heart Arrest
Humans
Respiration