Medical College of Wisconsin
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Progressive disease in chronic lymphocytic leukemia is correlated with the DNA methylation index. Leuk Res 2007 Jun;31(6):773-7 PMID: 16970987

Pubmed ID

16970987

Abstract

The DNA methylation index (MI) is calculated as a percentage of methylated cytosines to cytosines. We established the DNA MI in 100 normal individuals ranging in age between 1 month and 94 years and found that the age-specific DNA MI can be calculated (4.00-0.0034 x age). We determined the DNA MI in 23 patients with CLL ranging from 47 to 90 years and compared the results with age-matched controls. Using Cox proportional hazard models for MI, adjusting for age and white blood cell count, only the DNA MI correlated with early clinical indications for systemic therapy (p=0.0038, HR=7.00, 95% CI: 1.90-26.20).

Author List

Yu MK, Bergonia H, Szabo A, Phillips JD

Author

Aniko Szabo PhD Associate Professor in the Institute for Health and Equity department at Medical College of Wisconsin




Scopus

2-s2.0-34249827572   11 Citations

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Child
Child, Preschool
DNA Methylation
Disease Progression
Female
Humans
Infant
Leukemia, Lymphocytic, Chronic, B-Cell
Leukocyte Count
Male
Middle Aged
Proportional Hazards Models
jenkins-FCD Prod-299 9ef562391eceb2b8f95265c767fbba1ce5a52fd6