Faculty Collaboration Database

Acute graft-versus-host disease: a bench-to-bedside update. Blood 2014 Jul 17;124(3):363-73

Date

06/11/2014

Pubmed ID

24914140

Pubmed Central ID

PMC4102709

DOI

10.1182/blood-2014-01-514786

Scopus ID

2-s2.0-84904471984 (requires institutional sign-in at Scopus site)   159 Citations

Abstract

Over the past 5 years, many novel approaches to early diagnosis, prevention, and treatment of acute graft-versus-host disease (aGVHD) have been translated from the bench to the bedside. In this review, we highlight recent discoveries in the context of current aGVHD care. The most significant innovations that have already reached the clinic are prophylaxis strategies based upon a refinement of our understanding of key sensors, effectors, suppressors of the immune alloreactive response, and the resultant tissue damage from the aGVHD inflammatory cascade. In the near future, aGVHD prevention and treatment will likely involve multiple modalities, including small molecules regulating immunologic checkpoints, enhancement of suppressor cytokines and cellular subsets, modulation of the microbiota, graft manipulation, and other donor-based prophylaxis strategies. Despite long-term efforts, major challenges in treatment of established aGVHD still remain. Resolution of inflammation and facilitation of rapid immune reconstitution in those with only a limited response to corticosteroids is a research arena that remains rife with opportunity and urgent clinical need.

Author List

Holtan SG, Pasquini M, Weisdorf DJ

Author

Marcelo C. Pasquini MD, MS Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Acute Disease
Adrenal Cortex Hormones
Allografts
Animals
Antigen-Presenting Cells
Clinical Trials as Topic
Disease Models, Animal
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Histocompatibility Testing
Humans
T-Lymphocytes
Tissue Donors