Medical College of Wisconsin
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Gastrointestinal bleeding in patients on long-term dialysis. J Nephrol 2015 Apr;28(2):235-43 PMID: 25185727 PMCID: PMC4986509

Pubmed ID



BACKGROUND: The epidemiology of gastrointestinal bleeding (GIB) in end-stage renal disease (ESRD) has not been adequately characterized. Using United States Renal Data System data we investigated the epidemiology of GIB in hospitalized patients receiving long-term dialysis.

METHODS: Medicare ESRD patients who began dialysis between 1996 and 2005 were followed from 90 days after starting dialysis to death, transplant, loss of Medicare, or December 31, 2006. GIB events were identified using claims data. Predictors of GIB incidence were analyzed using over-dispersed Poisson regression and Cox regression was used to evaluate the effect on survival. Repeat episodes were modeled using a partially conditional Cox regression model.

RESULTS: 406,836 patients were followed for 832,131 person-years, during which 133,967 events were identified. The incidence of GIB was stable through year 2000 but steadily increased thereafter. Chronic gastric ulcer and colonic diverticulosis were the commonest defined causes of upper and lower GIB respectively. Age >49 years, female gender, hypertension as the cause of ESRD, and initiation on hemodialysis was associated with a greater risk of GIB. An episode of GIB conferred a increased hazard of death (hazard ratio 1.9, 95% CI 1.86-1.93). A previous episode of GIB was associated with greater hazard of another episode (hazard ratio 3.93, 95% CI 3.82-4.05).

CONCLUSIONS: In ESRD patients incident to long-term dialysis the incidence of hospital-associated GIB is increasing, is associated with a greater hazard of death, and carries a great hazard of repeat episodes.

Author List

Trivedi H, Yang J, Szabo A


Aniko Szabo PhD Associate Professor in the Institute for Health and Equity department at Medical College of Wisconsin


2-s2.0-84925935014   6 Citations

MESH terms used to index this publication - Major topics in bold

Administrative Claims, Healthcare
Age Factors
Aged, 80 and over
Child, Preschool
Diverticulosis, Colonic
Gastrointestinal Hemorrhage
Infant, Newborn
Kidney Failure, Chronic
Middle Aged
Renal Dialysis
Sex Factors
Stomach Ulcer
Time Factors
United States
Young Adult
jenkins-FCD Prod-299 9ef562391eceb2b8f95265c767fbba1ce5a52fd6