Faculty Collaboration Database

A nomogram to predict disease-free survival after surgical resection of GIST. J Gastrointest Surg 2014 Dec;18(12):2123-9

Date

09/24/2014

Pubmed ID

25245766

Pubmed Central ID

PMC4659361

DOI

10.1007/s11605-014-2658-2

Scopus ID

2-s2.0-84911988818 (requires institutional sign-in at Scopus site)   26 Citations

Abstract

BACKGROUND: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Adjuvant imatinib therapy has resulted in improved disease-free survival (DFS) following resection of primary GIST. The aim of our study was to create a nomogram to predict DFS following resection of GIST.

METHOD: Using a multi-institutional cohort of patients who underwent surgery for primary GIST at 7 academic hospitals in the USA and Canada between January 1998 and December 2012, a multivariable Cox proportional hazards model predicting DFS was created using backward stepwise selection. A nomogram to predict DFS following surgical resection of GIST was constructed with the variables selected in the multivariable model. We tested nomogram discrimination by calculating the C-statistic and compared the nomogram to four existing GIST prognostic stratification systems.

RESULTS: A total of 365 patients who underwent surgery for primary GIST was included in the study. Using backward stepwise selection, sex, tumor size, tumor site, and mitotic rate were selected for incorporation into the nomogram. The nomogram demonstrated superior discrimination compared to the NIH criteria, modified NIH criteria, and Memorial Sloan-Kettering Nomogram and had similar discrimination to the Miettinen criteria (C-statistic 0.77 vs 0.73, 0.71, 0.71, and 0.78, respectively).

CONCLUSION: Four independent predictors of recurrence following surgery for primary GIST were used to create a nomogram to predict DFS. The nomogram stratified patients into prognostic groups and performed well on internal validation.

Author List

Bischof DA, Kim Y, Behman R, Karanicolas PJ, Quereshy FA, Blazer DG 3rd, Maithel SK, Gamblin TC, Bauer TW, Pawlik TM

Author

Thomas Clark Gamblin MD Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged
Canada
Digestive System Surgical Procedures
Disease-Free Survival
Female
Gastrointestinal Neoplasms
Gastrointestinal Stromal Tumors
Humans
Incidence
Male
Middle Aged
Neoplasm Recurrence, Local
Nomograms
Retrospective Studies
United States