The emerging prominence of the cardiac mast cell as a potent mediator of adverse myocardial remodeling. Methods Mol Biol 2015;1220:121-39
Date
11/13/2014Pubmed ID
25388248Pubmed Central ID
PMC4422981DOI
10.1007/978-1-4939-1568-2_8Scopus ID
2-s2.0-84954610434 (requires institutional sign-in at Scopus site) 53 CitationsAbstract
Cardiac mast cells store and release a variety of biologically active mediators, several of which have been implicated in the activation of matrix metalloproteinases in the volume-overloaded heart, while others are involved in the fibrotic process in pressure-overloaded hearts. Increased numbers of mast cells have been reported in explanted human hearts with dilated cardiomyopathy and in animal models of experimentally induced hypertension, myocardial infarction, and chronic cardiac volume overload. Also, there is evolving evidence implicating the cardiac mast cell as having a major role in the adverse remodeling underlying these cardiovascular disorders. Thus, the cardiac mast cell is the focus of this chapter that begins with a historical background, followed by sections on methods for their isolation and characterization, endogenous secretagogues, phenotype, and ability of estrogen to alter their phenotype so as to provide cardioprotection. Finally the role of mast cells in myocardial remodeling secondary to a sustained cardiac volume overload, hypertension, and ischemic injury and future research directions are discussed.
Author List
Janicki JS, Brower GL, Levick SPMESH terms used to index this publication - Major topics in bold
AnimalsCell Separation
Heart Diseases
Humans
Mast Cells
Myocardium
Ventricular Remodeling