Volatile anesthetic-induced cardiac preconditioning. J Anesth 2007;21(2):212-9
Date
04/27/2007Pubmed ID
17458651DOI
10.1007/s00540-006-0486-6Scopus ID
2-s2.0-34247847849 (requires institutional sign-in at Scopus site) 54 CitationsAbstract
Pharmacological preconditioning with volatile anesthetics, or anesthetic-induced preconditioning (APC), is a phenomenon whereby a brief exposure to volatile anesthetic agents protects the heart from the potentially fatal consequences of a subsequent prolonged period of myocardial ischemia and reperfusion. Although not completely elucidated, the cellular and molecular mechanisms of APC appear to mimic those of ischemic preconditioning, the most powerful endogenous cardioprotective mechanism. This article reviews recently accumulated evidence underscoring the importance of mitochondria, reactive oxygen species, and K(ATP) channels in cardioprotective signaling by volatile anesthetics. Moreover, the article addresses current concepts and controversies regarding the specific roles of the mitochondrial and the sarcolemmal K(ATP) channels in APC.
Author List
Stadnicka A, Marinovic J, Ljubkovic M, Bienengraeber MW, Bosnjak ZJMESH terms used to index this publication - Major topics in bold
Anesthesia, InhalationAnesthetics, Inhalation
Animals
Humans
Ion Channels
Ischemic Preconditioning, Myocardial
Potassium
