How many sexually-acquired HIV infections in the USA are due to acute-phase HIV transmission? AIDS 2007 Jul 31;21(12):1625-9
Date
07/17/2007Pubmed ID
17630558Pubmed Central ID
PMC2377417DOI
10.1097/QAD.0b013e32826fb6a6Scopus ID
2-s2.0-34447527370 (requires institutional sign-in at Scopus site) 69 CitationsAbstract
OBJECTIVE: To estimate the number of persons in the USA who acquire HIV as a consequence of risky sexual activities with an acutely-infected sex partner.
METHODS: Estimates of the number of incident infections in the USA that are due to acute-phase HIV transmission were derived from a simple mathematical model that combined epidemiological data with information regarding the relative transmission rates for acutely-infected, nonacutely infected but serostatus-unaware, and serostatus-aware persons living with HIV.
RESULTS: Approximately 2760 (8.6%) of the estimated 32 000 sexually-acquired HIV infections in the USA each year are due to acute-phase transmission of the virus. Multivariate sensitivity analyses with a liberal range of values for key parameters produced an upper bound of 5537 infections, representing 17.3% of the total number of sexually-acquired infections.
CONCLUSIONS: Acute-phase HIV transmission accounts for fewer sexually-acquired infections in the USA than is generally assumed.
Author List
Pinkerton SDMESH terms used to index this publication - Major topics in bold
Acute DiseaseHIV Infections
Humans
Models, Biological
Sensitivity and Specificity
Sexual Behavior
Sexually Transmitted Diseases
United States