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Efficacy of recombinant human granulocyte colony stimulating factor in very-low-birth-weight infants with early neutropenia. J Formos Med Assoc 2015 Feb;114(2):174-9

Date

02/14/2015

Pubmed ID

25678180

DOI

10.1016/j.jfma.2012.10.009

Scopus ID

2-s2.0-84922767069   1 Citation

Abstract

BACKGROUND/PURPOSE: Neutropenia is a risk factor for nosocomial infections (NI) in very-low-birth-weight (VLBW) infants. Although recombinant human granulocyte colony stimulating factor (rhG-CSF) increases the neutrophil counts in neutropenic VLBW infants, its long-term efficacy for early neutropenia (EN) remains unknown.

METHODS: In this case-controlled study, charts of VLBW recipients of rhG-CSF for EN (total neutrophil count <1.5 × 10(9)/L during first 7 days) were reviewed and compared to gestational age, total neutrophil count, and birth weight matched infants unexposed to rhG-CSF.

RESULTS: Twenty-seven infants were identified in each group. Mortality and morbidity did not differ between the two groups. Rate of NI (16/27 vs. 4/27, p = 0.002, odds ratio = 8.36) as well as the total number of episodes of NI (22 vs. 4, p = 0.007) were higher in rhG-CSF (+) group than in the rhG-CSF (-) group.

CONCLUSION: Our experience does not show benefit in empirical use of rhG-CSF in preventing NI in VLBW infants with EN.

Author List

Teng RJ, Wu TJ, Sharma R, Garrison RD, Hudak ML

Authors

Ru-Jeng Teng MD Associate Professor in the Pediatrics department at Medical College of Wisconsin
Tzong-Jin Wu MD Associate Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Case-Control Studies
Cross Infection
Female
Florida
Gestational Age
Granulocyte Colony-Stimulating Factor
Humans
Infant
Infant, Newborn
Infant, Premature
Infant, Very Low Birth Weight
Intensive Care Units, Neonatal
Leukocyte Count
Logistic Models
Male
Multivariate Analysis
Neutropenia
Recombinant Proteins
jenkins-FCD Prod-398 336d56a365602aa89dcc112f077233607d6a5abc