Repetitive generalized seizure-like activity during emergence from sevoflurane anesthesia. Can J Anaesth 2007 Aug;54(8):657-61
Date
08/02/2007Pubmed ID
17666720DOI
10.1007/BF03022961Scopus ID
2-s2.0-34548094669 (requires institutional sign-in at Scopus site) 31 CitationsAbstract
PURPOSE: Sevoflurane-induced seizures are most often described during mask induction of anesthesia when high concentrations of the volatile agent are administered concomitant with alveolar hyperventilation. The occurrence of seizure-like activity during emergence from sevoflurane anesthesia has been rarely reported.
CLINICAL FEATURES: We describe a patient who developed several episodes of generalized tonic-clonic seizure-like activity during and immediately after emergence from sevoflurane anesthesia and discuss the potential factors that contributed to this unusual complication. The patient was treated with intravenous propofol, midazolam, and phenytoin and required intensive care management before his neurologic status stabilized.
CONCLUSION: The report emphasizes that sevoflurane is capable of producing excitatory central nervous system (CNS) phenomena in spite of causing primarily CNS depressant effects.
Author List
Mohanram A, Kumar V, Iqbal Z, Markan S, Pagel PSAuthor
Paul S. Pagel MD, PhD Professor in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAnesthesia Recovery Period
Anesthesia, Inhalation
Anesthetics, Inhalation
Humans
Hypnotics and Sedatives
Male
Methyl Ethers
Midazolam
Propofol
Secondary Prevention
Seizures