Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Effects of radiation upon gastrointestinal motility. World J Gastroenterol 2007 May 21;13(19):2684-92

Date

06/15/2007

Pubmed ID

17569136

Pubmed Central ID

PMC4147116

DOI

10.3748/wjg.v13.i19.2684

Scopus ID

2-s2.0-34250772243 (requires institutional sign-in at Scopus site)   25 Citations

Abstract

Whether due to therapeutic or belligerent exposure, the gastrointestinal effects of irradiation produce symptoms dreaded by a majority of the population. Nausea, vomiting, diarrhea and abdominal cramping are hallmarks of the prodromal phase of radiation sickness, occurring hours to days following radiation exposure. The prodromal phase is distinct from acute radiation sickness in that the absorptive, secretory and anatomic changes associated with radiation damage are not easily identifiable. It is during this phase of radiation sickness that gastrointestinal motility significantly changes. In addition, there is evidence that motor activity of the gut contributes to some of the acute and chronic effects of radiation.

Author List

Otterson MF

Author

Mary F. Otterson MD Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Anal Canal
Gastrointestinal Motility
Humans
Muscle Contraction
Muscle, Smooth
Radiation Injuries
Rectum