Candidate genes for hypertension: insights from the Dahl S rat. Am J Physiol Renal Physiol 2015 Dec 15;309(12):F993-5
Date
04/17/2015Pubmed ID
25877508Pubmed Central ID
PMC4839476DOI
10.1152/ajprenal.00092.2015Scopus ID
2-s2.0-84959205722 (requires institutional sign-in at Scopus site) 10 CitationsAbstract
Human genetic linkage and association studies have nominated many genes as possible contributors to disease. Mutating or deleting these genes in a relevant disease model can validate their association with disease and potentially uncover novel mechanisms of pathogenesis. Targeted genetic mutagenesis has only recently been developed in the rat, and this technique has been applied in the Dahl salt-sensitive (S) rat to investigate human candidate genes associated with hypertension. This mini-review communicates the findings of these studies and displays how targeted genetic mutagenesis may contribute to the discovery of novel therapies for patients.
Author List
Rudemiller NP, Mattson DLMESH terms used to index this publication - Major topics in bold
AnimalsBlood Pressure
Disease Models, Animal
Genetic Predisposition to Disease
Humans
Hypertension
Mutation
Rats, Inbred Dahl
Sodium Chloride