Why "R" HIT patients predisposed to thrombosis? Blood 2015 Apr 09;125(15):2319-20
Date
04/11/2015Pubmed ID
25858890DOI
10.1182/blood-2015-02-629782Scopus ID
2-s2.0-84927539359 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
In this issue of Blood, Rollin et al demonstrate that heparin-induced thrombocytopenia and thrombosis (HIT) patients homozygous for arginine (R) at position 131 in the immunoglobulin (Ig)G receptor FcγRIIA have a significantly higher incidence of thrombosis, and show that plasma IgG may play a key role in modulating the thrombotic process.
Author List
Padmanabhan AMESH terms used to index this publication - Major topics in bold
AnticoagulantsHeparin
Humans
Immunoglobulin G
Platelet Activation
Receptors, IgG
Thrombocytopenia
Thrombosis