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Transcription factor Stat5 synergizes with androgen receptor in prostate cancer cells. Cancer Res 2008 Jan 01;68(1):236-48



Pubmed ID




Scopus ID

2-s2.0-39149111601   81 Citations


The molecular mechanisms underlying progression of prostate cancer to the hormone-independent state are poorly understood. Signal transducer and activator of transcription 5a and 5b (Stat5a/b) is critical for the viability of human prostate cancer cells. We have previously shown that Stat5a/b is constitutively active in high-grade human prostate cancer, but not in normal prostate epithelium. Furthermore, activation of Stat5a/b in primary human prostate cancer predicted early disease recurrence. We show here that transcription factor Stat5a/b is active in 95% of clinical hormone-refractory human prostate cancers. We show for the first time that Stat5a/b synergizes with androgen receptor (AR) in prostate cancer cells. Specifically, active Stat5a/b increases transcriptional activity of AR, and AR, in turn, increases transcriptional activity of Stat5a/b. Liganded AR and active Stat5a/b physically interact in prostate cancer cells and, importantly, enhance nuclear localization of each other. The work presented here provides the first evidence of synergy between AR and the prolactin signaling protein Stat5a/b in human prostate cancer cells.

Author List

Tan SH, Dagvadorj A, Shen F, Gu L, Liao Z, Abdulghani J, Zhang Y, Gelmann EP, Zellweger T, Culig Z, Visakorpi T, Bubendorf L, Kirken RA, Karras J, Nevalainen MT


Marja T. Nevalainen MD, PhD Assistant Dean, Professor in the Pathology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Active Transport, Cell Nucleus
Cell Nucleus
Gene Expression Regulation, Neoplastic
Neoplasms, Hormone-Dependent
Prostatic Neoplasms
Protein Interaction Mapping
Receptors, Androgen
STAT5 Transcription Factor
Signal Transduction
Transcription, Genetic
Tumor Cells, Cultured
jenkins-FCD Prod-466 5b81815b8b3d1f46bfec16512ed5f574613f59c5