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Prolactin and prolactin receptors are expressed and functioning in human prostate. J Clin Invest 1997 Feb 15;99(4):618-27

Date

02/15/1997

Pubmed ID

9045863

Pubmed Central ID

PMC507843

DOI

10.1172/JCI119204

Scopus ID

2-s2.0-0031030299   163 Citations

Abstract

Prolactin is widely expressed in different tissues, and it is presumed to have both local and systemic actions. In males it is known to influence reproductive functions but the significance and mechanisms of prolactin action in male accessory reproductive tissues are poorly understood. Here we show that prolactin acts as a direct growth and differentiation factor for human prostate, as measured by changes in DNA synthesis and epithelial morphology of organ cultures. Furthermore, we report the expression in human prostate of a short prolactin receptor form in addition to the long form, based upon ligand cross-linking studies and RT-PCR analysis of mRNA expression. The highest density of prolactin receptors was detected in the secretory epithelial cells by immunohistochemistry. Finally, we report that prolactin is locally produced in human prostate epithelium, as evidenced by marked prolactin immunoreactivity in a significant portion of prostate epithelial cells, with parallel expression of prolactin mRNA in human prostate. Collectively, these data provide significant support for the existence of an autocrine/paracrine loop of prolactin in the human prostate and may shed new light on the involvement of prolactin in the etiology and progression of neoplastic growth of the prostate.

Author List

Nevalainen MT, Valve EM, Ingleton PM, Nurmi M, Martikainen PM, Harkonen PL

Author

Marja T. Nevalainen MD, PhD Assistant Dean, Professor in the Pathology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Aged
DNA
Epithelium
Humans
Male
Middle Aged
Molecular Weight
Organ Culture Techniques
Prolactin
Prostate
RNA, Messenger
Receptors, Prolactin
jenkins-FCD Prod-400 0f9a74600e4e79798f8fa6f545ea115f3dd948b2