Wilms tumor presenting with Lambert-Eaton myasthenic syndrome. J Pediatr Hematol Oncol 2013 May;35(4):267-70
Date
04/25/2013Pubmed ID
23612377DOI
10.1097/MPH.0b013e31828d46a7Scopus ID
2-s2.0-84878633190 (requires institutional sign-in at Scopus site) 2 CitationsAbstract
Paraneoplastic syndromes may affect the central and peripheral nervous system of adults and children with cancer. Neurological symptoms may resolve with treatment of the underlying neoplasm. We report the case of a child with Wilms tumor who presented with generalized weakness, fatigue, ptosis, hypokinesis, dysarthria, urinary retention, facial diplegia, ophthalmoplegia, and autonomic dysfunction. Routine electrodiagnostic testing, including repetitive nerve stimulation, was normal. Clinical features and stimulation single-fiber electromyogram were consistent with a neuromuscular junction transmission disorder, likely Lambert-Eaton myasthenic syndrome. The child's neurological status returned to normal with successful treatment of the tumor.
Author List
Petersen CL, Hemker BG, Jacobson RD, Warwick AB, Jaradeh SS, Kelly MEMESH terms used to index this publication - Major topics in bold
Child, PreschoolHumans
Kidney Neoplasms
Lambert-Eaton Myasthenic Syndrome
Male
Wilms Tumor