Melatonin-analog, beta-methyl-6-chloromelatonin, supplementation in spinal cord injury. Brain Res 2010 Jun 22;1340:81-5
Date
04/28/2010Pubmed ID
20420812DOI
10.1016/j.brainres.2010.04.047Scopus ID
2-s2.0-77953121482 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
Spinal cord injury (SCI) is a devastating condition. Melatonin supplementation has been shown to lessen SCI, but its use has been limited by its side effect profile. In this work, rats underwent a moderate-to-severe contussional SCI with either placebo or beta-methyl-6-chloromelatonin, 10mg/kg or 100mg/kg supplementation. The 10mg/kg supplementation demonstrated benefit; the 100mg/kg dosage was limited by toxicity. This is the first work to assess a melatonin analog in SCI.
Author List
Fee DB, Swartz KR, Scheff N, Roberts K, Gabbita P, Scheff SAuthors
Dominic B. Fee MD Vice Chair, Professor in the Neurology department at Medical College of WisconsinKarin R. Swartz MD Assistant Dean, Professor in the Neurosurgery department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsDietary Supplements
Disease Models, Animal
Dose-Response Relationship, Drug
Female
Melatonin
Neurons
Neuroprotective Agents
Rats
Rats, Sprague-Dawley
Spinal Cord
Spinal Cord Injuries