Hemorrhagic disease of the newborn despite vitamin K prophylaxis at birth. Pediatr Blood Cancer 2008 May;50(5):1075-7
Date
10/25/2007Pubmed ID
17957759DOI
10.1002/pbc.21383Scopus ID
2-s2.0-41849099695 (requires institutional sign-in at Scopus site) 25 CitationsAbstract
Late hemorrhagic disease of the newborn (HDN) presents 0.5-6 months after birth with mucocutaneous and intracranial bleeding. We describe here two cases of late HDN in infants who received vitamin K. The first case is a previously healthy breastfed male who received one dose of oral vitamin K at birth and developed an intracranial hemorrhage 5 weeks later. He was treated with intravenous vitamin K and recombinant factor VIIa prior to emergent craniectomy. An unrelated infant presented at 5 months of age with diarrhea and easy bruising despite IM vitamin K at birth. These cases illustrate the morbidity associated with late HDN.
Author List
Flood VH, Galderisi FC, Lowas SR, Kendrick A, Boshkov LKAuthor
Veronica H. Flood MD Interim Chief, Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Factor VIIaHumans
Infant
Infant, Newborn
Male
Recombinant Proteins
Vitamin K
Vitamin K Deficiency
Vitamin K Deficiency Bleeding
Vitamins