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Changes in perfusion and diffusion in the endplate regions of degenerating intervertebral discs: a DCE-MRI study. Eur Spine J 2015 Nov;24(11):2458-67 PMID: 26238936 PMCID: PMC4755697

Abstract

PURPOSE: Dynamic contrast-enhanced MRI (DCE-MRI) was used to investigate the associations between intervertebral disc degeneration and changes in perfusion and diffusion in the disc endplates.

METHODS: 56 participants underwent MRI scans. Changes in DCE-MRI signal enhancement in the endplate regions were analyzed. Also, a group template was generated for the endplates and enhancement maps were registered to this template for group analysis.

RESULTS: DCE-MRI enhancement changed significantly in cranial endplates with increased degeneration. A similar trend was observed for caudal endplates, but it was not significant. Group-averaged enhancement maps revealed major changes in spatial distribution of endplate perfusion and diffusion with increasing disc degeneration especially in peripheral endplate regions.

CONCLUSIONS: Increased enhancement in the endplate regions of degenerating discs might be an indication of ongoing damage in these tissues. Therefore, DCE-MRI could aid in understanding the pathophysiology of disc degeneration. Moreover, it could be used in the planning of novel treatments such as stem cell therapy.

Author List

Arpinar VE, Rand SD, Klein AP, Maiman DJ, Muftuler LT

Authors

Andrew P. Klein MD Assistant Professor in the Radiology department at Medical College of Wisconsin
Dennis J. Maiman MD, PhD Professor in the Neurosurgery department at Medical College of Wisconsin
Lutfi Tugan Muftuler PhD Associate Professor in the Neurosurgery department at Medical College of Wisconsin
Scott D. Rand MD, PhD Professor in the Radiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Case-Control Studies
Contrast Media
Diffusion
Female
Humans
Lumbar Vertebrae
Magnetic Resonance Imaging
Male
Middle Aged



View this publication's entry at the Pubmed website PMID: 26238936
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