Angiolymphoid hyperplasia with eosinophilia (epithelioid hemangioma) of the lung: a clinicopathologic and immunohistochemical study of two cases. Am J Clin Pathol 2005 May;123(5):762-5
Date
06/29/2005Pubmed ID
15981816Scopus ID
2-s2.0-17844404830 (requires institutional sign-in at Scopus site) 23 CitationsAbstract
Two cases of primary angiolymphoid hyperplasia with eosinophilia (epithelioid hemangioma) (ALHE/EH) of the lung are described. Both patients are white, a 60-year-old man and a 27-year-old woman. One patient had a long-standing history of asthma, and the other had symptomatology related to the pulmonary mass. Wedge resections were performed in both cases, and both lesions shared similar histopathologic changes, mainly the presence of a tumor mass with a marked presence of eosinophils in the background, lymphoid hyperplasia, and marked proliferations of small-caliber vessels. Immunohistochemical studies using leukocyte common antigen, L-26, and UCHL-1 nicely stained the lymphoid component of the lesion, and CD31 clearly outlined the vascular component of the process. Clinical follow-up demonstrated that the woman died of status asthmaticus, and the man was alive and well 1 year after surgical resection of the lesion. Both cases highlight the ubiquitous distribution of ALHE/EH and underscore the importance of keeping these lesions in the differential diagnosis of vascular and lymphoid lesions of the lung.
Author List
Moran CA, Suster SMESH terms used to index this publication - Major topics in bold
AdultAngiolymphoid Hyperplasia with Eosinophilia
Antigens, CD20
Asthma
Biomarkers
Fatal Outcome
Female
Humans
Leukocyte Common Antigens
Lung Diseases
Male
Middle Aged
Platelet Endothelial Cell Adhesion Molecule-1
