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Preliminary Evaluation of the Research-Use-Only (RUO) iCubate iC-GPC Assay for Identification of Select Gram-Positive Bacteria and Their Resistance Determinants in Blood Culture Broths. J Clin Microbiol 2015 Dec;53(12):3931-4

Date

10/16/2015

Pubmed ID

26468498

Pubmed Central ID

PMC4652113

DOI

10.1128/JCM.01934-15

Scopus ID

2-s2.0-84947731492 (requires institutional sign-in at Scopus site)   5 Citations

Abstract

The iC-GPC assay (iCubate, Huntsville, AL) provides a molecular option for the rapid, on-demand analysis of positive blood cultures. A preliminary evaluation of the iC-GPC assay using 203 clinical or seeded specimens demonstrated a sensitivity of 93.8% to 100% and a specificity of 98.0% to 100% for the identification of five Gram-positive bacterial species (Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Enterococcus faecalis, and Enterococcus faecium) and three associated genetic resistance determinants (mecA, vanA, and vanB) in positive blood culture broths.

Author List

Buchan BW, Reymann GC, Granato PA, Alkins BR, Jim P, Young S

Author

Blake W. Buchan PhD Professor in the Pathology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Bacteriological Techniques
Drug Resistance, Bacterial
Genes, Bacterial
Genotype
Gram-Positive Bacteria
Gram-Positive Bacterial Infections
Humans
Molecular Diagnostic Techniques
Sensitivity and Specificity