Medical College of Wisconsin
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Health-related Quality of Life in Infants With Sickle Cell Disease. J Pediatr Hematol Oncol 2015 Nov;37(8):590-4 PMID: 26479994

Pubmed ID





Using historical cohorts of healthy, acutely ill, and chronically ill infants for comparison, we sought to determine whether infants with sickle cell disease (SCD) have impaired health-related quality of life (HRQL). We conducted a cross-sectional study at 2 sites: the Medical College of Wisconsin/Children's of Wisconsin and the University of Alabama School of Medicine/Children's of Alabama. Parents of 90 infants with SCD completed the PedsQL Infant Module corresponding to their infant's age (1 to 12 mo or 13 to 24 mo) during a regular clinic visit. At 1 to 12 months, infants with SCD displayed lower Physical HRQL than healthy infants, but better HRQL than chronically ill infants. By 13 to 24 months, infants with SCD had worse HRQL in all areas than healthy infants and worse Physical and Total HRQL than acutely ill infants. Compared with chronically ill infants in this age group, infants with SCD had similar Physical HRQL and better Psychosocial and Total HRQL. By 13 to 24 months, a greater proportion of infants with SCD had impaired Physical and Total HRQL compared with infants aged 1 to 12 months. All differences were significant at the (P<0.05) level. Impaired HRQL can be detected in infants with SCD.

Author List

Beverung LM, Bemrich-Stolz C, Torres S, Panepinto JA


Julie A. Panepinto MD, MSPH Professor in the Pediatrics department at Medical College of Wisconsin



MESH terms used to index this publication - Major topics in bold

Acute Disease
Anemia, Sickle Cell
Child, Preschool
Chronic Disease
Cross-Sectional Studies
Psychology, Child
Quality of Life
Symptom Assessment
jenkins-FCD Prod-310 bff9d975ec7f2d302586822146c2801dd4449aad